AI-Enabled Parkinson’s Disease Screening Using Smile Videos

Published in NEJM AI, 2025

We developed a facial micro-expression analysis framework to distinguish Parkinson’s disease (PD) using short smile videos, achieving strong classification accuracy and generalizability across international cohorts. The model attained $\mathbf{\sim88\%}$ accuracy using only consumer-grade cameras, demonstrating the potential for remote and accessible PD screening.

Recommended citation: Adnan, T., Islam, M.S., Lee, S., Wasifur Rahman Chowdhury, E.M., Tithi, S.D., Noshin, K., Islam, M.R., Sarker, I., Rahman, M.S., Schneider, R.B. and Adams, J.L., 2025. AI-Enabled Parkinson’s Disease Screening Using Smile Videos. NEJM AI, 2(7), p.AIoa2400950.
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